The stratigraphy, correlation, provenance and palaeogeography of the Skiddaw Group (Ordovician) in the English Lake District

A new lithostratigraphy is presented for the Skiddaw Group (lower Ordovician) of the English Lake District. Two stratigraphical belts are described. Five formations are defined in the Northern Fells Belt, ranging in age from Tremadoc to early Llanvirn. They are all mudstone or sandstone dominated, of turbidite origin; in ascending order they are named the Bitter Beck, Watch Hill, Hope Beck, Loweswater and Kirk Stile formations. Two formations are defined in the Central Fells Belt, ranging in age from late Arenig to Llanvirn. These are the Buttermere Formation - a major olistostrome deposit - overlain by the Tarn Moor Formation, consisting of turbidite mudstones with volcaniclastic turbidite sandstone beds. A revised graptolite and new acritarch biostratigraphy for the Skiddaw Group is presented with eight graptolite biozones and thirteen acritarch assemblages and sub-assemblages. The provenance of the group is assessed from detailed petrographical and geochemical work. This suggests derivation, in the early Ordovician, largely from an old inactive continental arc terrane lying to the south-east, with the appearance of juvenile volcanic material in the Llanvirn. Comparisons and correlations of the Skiddaw Group are made with the Isle of Man and eastern Ireland

Reducing smoking in adolescents: cost-effectiveness results from the cluster randomized ASSIST (A Stop Smoking In Schools Trial)

Introduction: School-based smoking prevention programmes can be effective, but evidence on cost-effectiveness is lacking. We conducted a cost-effectiveness analysis of a school-based “peer-led” intervention.<p></p> Methods: We evaluated the ASSIST (A Stop Smoking In Schools Trial) programme in a cluster randomized controlled trial. The ASSIST programme trained students to act as peer supporters during informal interactions to encourage their peers not to smoke. Fifty-nine secondary schools in England and Wales were randomized to receive the ASSIST programme or usual smoking education. Ten thousand seven hundred and thirty students aged 12–13 years attended participating schools. Previous work has demonstrated that the ASSIST programme achieved a 2.1% (95% CI = 0%–4.2%) reduction in smoking prevalence. We evaluated the public sector cost, prevalence of weekly smoking, and cost per additional student not smoking at 24 months.<p></p> Results: The ASSIST programme cost of £32 (95% CI = £29.70–£33.80) per student. The incremental cost per student not smoking at 2 years was £1,500 (95% CI = £669–£9,947). Students in intervention schools were less likely to believe that they would be a smoker at age 16 years (odds ratio [OR] = 0.80; 95% CI = 0.66–0.96).<p></p> Conclusions: A peer-led intervention reduced smoking among adolescents at a modest cost. The intervention is cost-effective under realistic assumptions regarding the extent to which reductions in adolescent smoking lead to lower smoking prevalence and/or earlier smoking cessation in adulthood. The annual cost of extending the intervention to Year 8 students in all U.K. schools would be in the region of £38 million and could result in 20,400 fewer adolescent smokers.<p></p&gt

The link between catchment precipitation forecast skill and spread to that of downstream ensemble hydrological forecasts

Operational rainfall and flood forecasting systems across the world are increasingly using ensemble approaches. Such systems are operated by the Flood Forecasting Centre (FFC) and Scottish Flood Forecasting Service (SFFS) across Great Britain producing ensemble gridded hydrological forecasts for the next 5-6 days. In order to maximise the practical day-to-day use of these systems for decision-making and warning, duty hydro-meteorologists require a sound understanding of both the meteorological and hydrological ensemble forecast skill. In this work, a common verification framework is defined and used in order to understand the relative levels of skill in both rainfall and river flow forecasting systems. A blended 24-member ensemble precipitation forecast, produced by the Met Office, is used to drive the operational distributed hydrological model in ensemble mode. The hydrological forecasts provide output every 15 minutes out to 6 days on a 1km grid. The blended rainfall forecast is a mixture of the 2.2 km MOGREPS-UK ensemble up to 36h and the 32 km global MOGREPS-G ensemble at longer lead-times. The forecasts are interpolated on to a common 2 km grid and the hydrological model used is the Grid-to-Grid model (G2G) developed by the Centre for Ecology & Hydrology. To establish an upper bound on skill, assessments over a daily lead-time interval are studied first, and will be the focus here. Spatial and regional variations in forecast skill are compared between the precipitation (e.g. daily accumulations) and the river flow forecasts. Also of interest is the impact of catchment size and how to pool and present the skill metrics in a meaningful way for end-users. For precipitation, the impact of observation type: gridded gauge-only analyses and a radar-derived (gauge calibrated) precipitation product, is compared to quantify the uncertainty that comes from the observations. Of particular interest is understanding how the spread in the precipitation forecast is modulated by the downstream hydrological model. Is it inflated, does it remain comparable, or is it reduced? The work aims to establish the basis for a real-time monitoring tool that can assist hydro-meteorologists in their interpretation of operational ensemble forecasts, and facilitate associated decision making processes

Control methods for Dermanyssus gallinae in systems for laying hens: results of an international seminar

This paper reports the results of a seminar on poultry red mite (PRM), Dermanyssus gallinae. Eighteen researchers from eight European countries discussed life cycle issues of the mite, effects of mites on hens and egg production, and monitoring and control methods for PRM in poultry facilities. It was determined that PRM probably causes more damage than envisaged, with the cost in The Netherlands alone reaching 11 million euro per annum. However a great deal is still unknown about PRM (e.g. reproduction, survival methods, etc.) and that PRM monitoring is an important instrument in recognising and admitting the problem and in taking timely measures. Currently, the most promising control method combines heating the hen house in combination with chemical treatments. Future areas of development which show promise include the use of entomopathogenic fungi, vaccination and predatory mites. The final aim is to solve the problem of D. gallinae in housing systems for laying hens

Doppler-Free Spectroscopy of Weak Transitions: An Analytical Model Applied to Formaldehyde

Experimental observation of Doppler-free signals for weak transitions can be greatly facilitated by an estimate for their expected amplitudes. We derive an analytical model which allows the Doppler-free amplitude to be estimated for small Doppler-free signals. Application of this model to formaldehyde allows the amplitude of experimentally observed Doppler-free signals to be reproduced to within the experimental error.Comment: 7 pages, 7 figures, 1 table, v2: many small improvements + corrected line assignmen

A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding

In bacterial c-type cytochromes, the haem cofactor is covalently attached via two cysteine residues organized in a haem c-binding motif. Here, a novel octa-haem c protein, MccA, is described that contains only seven conventional haem c-binding motifs (CXXCH), in addition to several single cysteine residues and a conserved CH signature. Mass spectrometric analysis of purified MccA from Wolinella succinogenes suggests that two of the single cysteine residues are actually part of an unprecedented CX15CH sequence involved in haem c binding. Spectroscopic characterization of MccA identified an unusual high-potential haem c with a red-shifted absorption maximum, not unlike that of certain eukaryotic cytochromes c that exceptionally bind haem via only one thioether bridge. A haem lyase gene was found to be specifically required for the maturation of MccA in W. succinogenes. Equivalent haem lyase-encoding genes belonging to either the bacterial cytochrome c biogenesis system I or II are present in the vicinity of every known mccA gene suggesting a dedicated cytochrome c maturation pathway. The results necessitate reconsideration of computer-based prediction of putative haem c-binding motifs in bacterial proteomes

On the Sunyaev-Zel'dovich effect from dark matter annihilation or decay in galaxy clusters

We revisit the prospects for detecting the Sunyaev Zel'dovich (SZ) effect induced by dark matter (DM) annihilation or decay. We show that with standard (or even extreme) assumptions for DM properties, the optical depth associated with relativistic electrons injected from DM annihilation or decay is much smaller than that associated with thermal electrons, when averaged over the angular resolution of current and future experiments. For example, we find: $\tau_{\rm DM} \sim 10^{-9}-10^{-5}$ (depending on the assumptions) for \mchi = 1 GeV and a density profile $\rho\propto r^{-1}$ for a template cluster located at 50 Mpc and observed within an angular resolution of $10"$, compared to $\tau_{\rm th}\sim 10^{-3}-10^{-2}$. This, together with a full spectral analysis, enables us to demonstrate that, for a template cluster with generic properties, the SZ effect due to DM annihilation or decay is far below the sensitivity of the Planck satellite. This is at variance with previous claims regarding heavier annihilating DM particles. Should DM be made of lighter particles, the current constraints from 511 keV observations on the annihilation cross section or decay rate still prevent a detectable SZ effect. Finally, we show that spatial diffusion sets a core of a few kpc in the electron distribution, even for very cuspy DM profiles, such that improving the angular resolution of the instrument, e.g. with ALMA, does not necessarily improve the detection potential. We provide useful analytical formulae parameterized in terms of the DM mass, decay rate or annihilation cross section and DM halo features, that allow quick estimates of the SZ effect induced by any given candidate and any DM halo profile.Comment: 27 p, 6 figs, additional section on spatial diffusion effects. Accepted for publication in JCA

Myers' type theorems and some related oscillation results

In this paper we study the behavior of solutions of a second order differential equation. The existence of a zero and its localization allow us to get some compactness results. In particular we obtain a Myers' type theorem even in the presence of an amount of negative curvature. The technique we use also applies to the study of spectral properties of Schroedinger operators on complete manifolds.Comment: 16 page

Numerical studies of the two- and three-dimensional gauge glass at low temperature

We present results from Monte Carlo simulations of the two- and three-dimensional gauge glass at low temperature using the parallel tempering Monte Carlo method. Our results in two dimensions strongly support the transition being at T_c=0. A finite-size scaling analysis, which works well only for the larger sizes and lower temperatures, gives the stiffness exponent theta = -0.39 +/- 0.03. In three dimensions we find theta = 0.27 +/- 0.01, compatible with recent results from domain wall renormalization group studies.Comment: 7 pages, 10 figures, submitted to PR

String Imprints from a Pre-inflationary Era

We derive the equations governing the dynamics of cosmic strings in a flat anisotropic universe of Bianchi type I and study the evolution of simple cosmic string loop solutions. We show that the anisotropy of the background can have a characteristic effect in the loop motion. We discuss some cosmological consequences of these findings and, by extrapolating our results to cosmic string networks, we comment on their ability to survive an inflationary epoch, and hence be a possible fossil remnant (still visible today) of an anisotropic phase in the very early universe.Comment: 5 pages, 3 figure